Michael P. 詹森

教育

Ph.D., Northwestern University

B.S., California Institute of Technology

课程

• CHEM 4760 Modern Inorganic 化学 Fall Semester
• CHEM 4760L Advanced Inorganic Laboratory Fall Semester
• CHEM 7750 Theoretical Inorganic 化学 Spring Semester

研究

• Inorganic 化学

研究 in the 詹森 Group is focused on transition metal coordination chemistry. We prepare small molecule complexes as active-site models for redox-active metalloenzymes that catalyze environmentally significant reactions. We address synthetic, 结构, and mechanistic questions with respect to these enzymes that enable us to explore new coordination chemistry and exploit novel structures and reactivity.

Our strategy is exemplified by synthesis of hydrotris(pyrazolyl)borato (“Tp”) complexes of nickel(II) with dithiocarbamate co-ligands as models for nickel-dependent superoxide dismutases (e.g., D. P. Barondeau, 等. 生物化学 2004, 43, 8038). A key feature of the enzyme active is an [N₃S₂]^3- ligand field with an axial His-1 imidazole donor that stabilizes a Ni(II)/Ni(III) redox couple during substrate turnover. Similar to the enzyme, synthetic [TpNiS₂中国北车₂] complexes adopt either low-spin (square-planar) or high-spin (square-pyramidal) geometries that enable solid-state spin crossover as well as a reversible one-electron redox couple in a range suitable for SOD activity. A key mechanistic question now accessible to biomimetic studies is the role of axial base ligation in controlling the spin state and redox chemistry.

We are also interested in the general ability of thiolate and phenolate ligands to induce oxido-reductase activity within small molecule Ni(II) complexes. For example, we prepared [TpNiOAr] complexes that decompose under O₂, resulting in oxidative modification of aromatic C–H and C=C bonds. Analogous chemistry has been exploited to develop a new class of scorpionate-supported catalysts for nitrene transfer.

本科 and graduate students joining our research team will have the opportunity to participate in cutting-edge work and to learn a wide variety of modern synthetic and analytical techniques. Our results have been presented at regional, national and international meetings, and are published in leading academic journals (vide infra). Recent alumni have continued on to graduate studies or have obtained employment in higher education or in chemical industry.

Selected Publications

Tapash Deb 迈克尔·P. 詹森. ”Electrophilic Alkylation of Pseudotetrahedral Nickel(II) Arylthiolate Complexes.” Inorg. 化学. 2015, 54, 87-96.

Tapash Deb, Caitlin M. Anderson, Swarup Chattopadhyay, Huaibo Ma, Victor G. 年轻的小. 迈克尔·P. 詹森. ”Steric and electronic effects on arylthiolate coordination in the pseudotetrahedral complexes [(TpPh,Me)Ni - SAr] (TpPh,Me = hydrotris{3-phenyl-5-methyl-1-pyrazolyl}borate).” Dalton Transactions 2014, 43, 17489-17499.

Shengwen Liang 迈克尔·P. 詹森. “Half-sandwich scorpionates as nitrene transfer catalysts.” 有机金属化合物 2012, 31, 8055-8058.

Shengwen Liang, Haoshuang Wang, Tapash Deb, Jeffrey L. Petersen——戈登·T. Yee, 迈克尔·P. 詹森. “Structural and spectroscopic trends in a series of half-sandwich scorpionate complexes.” Inorg. 化学. 2012, 51, 12707-12719.

Tapash Deb, Gregory T. 罗德，维克多·G. 年轻的小. 迈克尔·P. 詹森. “Aerobic and hydrolytic decomposition of pseudotetrahedral nickel phenolate complexes.” Inorg. 化学. 2012, 51, 7257-7270.

Huaibo Ma, Jeffrey L. Petersen, Victor G. 年轻的小.——戈登·T. Yee, 迈克尔·P. 詹森. "Solid-State Spin Crossover of Ni(II) in a Bioinspired N₃S₂ 配位场." J. Am. 化学. Soc. 2011, 133, 5644-5647.